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Risk factors for C diff infections include conditions associated with altered intestinal bacterial flora, notably:
- Patient age >65 years
- Prior antibiotic exposure (including broad-spectrum penicillins, cephalosporins, clindamycin, and, to a lesser extent, aminoglycosides, antipseudomonals, metronidazole, and vancomycin)
- Use of certain immunosuppressants (eg, fluorouracil, methotrexate)
Children are more likely to carry asymptomatic C diff in their intestinal tracts than are adults.
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