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Prevention strategies include optimizing antibiotic stewardship to minimize the duration of antibiotic exposure and inappropriate agent selection, rigorous infection control practices to reduce person-to-person transmission, and aggressive environmental cleaning to minimize spore transmission. Environmental contamination with C diff bacteria and spores is associated with increased hand contamination of healthcare workers, which can be reduced by increased compliance to hand hygiene with soap and water. Of note, C diff spores are not killed by alcohol hand wash.
There are many EPA-approved products with efficacy against the vegetative forms of C diff, but only products with activity against spores can be used to fully control environmental contamination. Infection control practices that emphasize environmental disinfection with 10% sodium hypochlorite or quaternary ammonium-based products have been shown to reduce CDAD case rates.
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